One of only six senior men's players to reach 100 caps, O'Shea made his senior debut against Croatia at the old Lansdowne Road in 2001 and has played for Ireland in every calendar year since then.
An underage star, who helped the Ireland Under 16s win the UEFA European Championships in 1998, O'Shea went on to captain his country 17 times and appear at both EURO 2012 and EURO 2016.
Ireland manager Martin O'Neill saluted O'Shea by saying: "John has had a great career internationally and played at the very top at club level with Manchester United, where he won a lot of trophies.
"For any player to get over 100 caps is a magnificent feat and he can be very proud of that achievement. I will always remember John's goal away to Germany in Gelsenkirchen. He doesn't score too many goals so that made it even more special.
"I wish John the very best for the future and I'm sure he will become an excellent coach. And if he wants to I'm sure he has the capabilities of becoming a manager too."
FAI CEO John Delaney believes history will remember O'Shea as one of Ireland's greatest ever servants and that he deserves to be lauded for his performances as much as for his longevity.
"We have been very fortunate to have had some truly outstanding servants pull on the Republic of Ireland jersey and John O'Shea is most definitely one of those. When you watched him play it was clear to see how much it meant to him to be representing his country and that kind of commitment inspired players and supporters across many generations," said Delaney.
"A proud Waterford man, who was given a great introduction to football by Ferrybank and Waterford Bohemians, John always gave everything for Ireland and that is evidenced by the fact that he played international football for 17 consecutive years. That is a remarkable achievement and explains why he has always been a firm favourite amongst the Ireland supporters.
"John is one of the most decorated Irish players of the modern era due to his tremendous success with Manchester United, but he will be known more for his leadership - on and off the pitch. Whether it was with Sunderland or Ireland, John led by example and others followed. Just like his father, Jim, who was a gentleman, John has and always will be a passionate supporter of Irish football.
"We will pay tribute to John at the United States game on June 2. I hope the Ireland supporters will turn out in force to give a deserved send-off to one of the most committed players ever to pull on the green jersey."
O'Shea started 111 of his 117 senior appearances - winning 46 of them - and appeared in six UEFA European Championship games. He is currently the third most capped men's player behind Shay Given and Robbie Keane.
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John O'Shea International Career
Caps: 117
Goals: 3
Debut: v Croatia, Lansdowne Road, August 15, 2001
First Goal: v Australia, Lansdowne Road, August 19, 2003
List of Games Played
15/08/2001: Ireland 2-2 Croatia, Lansdowne Road
20/11/2002: Greece 0-0 Ireland, Athens
12/02/2003: Scotland 0-2 Ireland, Glasgow
29/03/2003: Georgia 1-2 Ireland, Tbilisi
02/04/2003: Albania 0-0 Ireland, Tirana
07/06/2003: Ireland 2-1 Albania, Lansdowne Road
11/06/2003: Ireland 2-0 Georgia, Lansdowne Road
19/08/2003: Ireland 2-1 Australia, Lansdowne Road
06/09/2003: Ireland 1-1 Russia, Lansdowne Road
11/10/2003: Switzerland 2-0 Ireland, Basel
18/11/2003: Ireland 3-0 Canada, Lansdowne Road
18/02/2004: Ireland 0-0 Brazil, Lansdowne Road
28/04/2004: Poland 0-0 Ireland, Bydgoszcz
02/06/2004: Jamaica 0-1 Ireland, London
18/08/2004: Ireland 1-1 Bulgaria, Lansdowne Road
04/09/2004: Ireland 3-0 Cyprus, Lansdowne Road
09/10/2004: France 0-0 Ireland, Paris
13/10/2004: Ireland 2-0 Faroe Islands, Lansdowne Road
16/11/2004: Ireland 1-0 Croatia, Lansdowne Road
09/02/2005: Ireland 1-0 Portugal, Lansdowne Road
26/03/2005: Israel 1-1 Ireland, Tel Aviv
29/03/2005: Ireland 1-0 China, Lansdowne Road
04/06/2005: Ireland 2-2 Israel, Lansdowne Road
08/06/2005: Faroe Islands 0-2 Ireland, Torshavn
17/08/2005: Ireland 1-2 Italy, Lansdowne Road
07/09/2005: Ireland 0-1 France, Lansdowne Road
08/10/2005: Cyprus 0-1 Ireland, Nicosia
12/10/2005: Ireland 0-0 Switzerland, Lansdowne Road
01/03/2006: Ireland 3-0 Sweden, Lansdowne Road
24/05/2006: Ireland 0-1 Chile, Lansdowne Road
16/08/2006: Ireland 0-4 Netherlands, Lansdowne Road
02/09/2006: Germany 1-0 Ireland, Stuttgart
07/10/2006: Cyprus 5-2 Ireland, Nicosia
11/10/2006: Ireland 1-1 Czech Republic, Lansdowne Road
15/11/2006: Ireland 5-0 San Marino, Lansdowne Road
07/02/2007: San Marino 1-2 Ireland, Serravalle
24/03/2007: Ireland 1-0 Wales, Croke Park
28/03/2007: Ireland 1-0 Slovakia, Croke Park
22/08/2007: Denmark 0-4 Ireland, Aarhus
08/09/2007: Slovakia 2-2 Ireland, Bratislava
12/09/2007: Czech Republic 1-0 Ireland, Prague
17/10/2007: Ireland 1-1 Cyprus, Croke Park
17/11/2007: Wales 2-2 Ireland, Cardiff
06/02/2008: Ireland 0-1 Brazil, Croke Park
29/05/2008: Ireland 1-0 Colombia, London
20/08/2008: Norway 1-1 Ireland, Oslo
06/09/2008: Georgia 1-2 Ireland, Mainz
10/09/2008: Montenegro 0-0 Ireland, Podgorica
15/10/2008: Ireland 1-0 Cyprus, Croke Park
19/11/2008: Ireland 2-3 Poland, Croke Park
11/02/2009: Ireland 2-1 Georgia, Croke Park
28/03/2009: Ireland 1-1 Bulgaria, Croke Park
01/04/2009: Italy 1-1 Ireland, Bari
06/06/2009: Bulgaria 1-1 Ireland, Sofia
12/08/2009: Ireland 0-3 Australia, Thomond Park
05/09/2009: Cyprus 1-2 Ireland, Nicosia
10/10/2009: Ireland 2-2 Italy, Croke Park
14/10/2009: Ireland 0-0 Montenegro, Croke Park
14/11/2009: Ireland 0-1 France, Croke Park
18/11/2009: France 1-1 Ireland, Paris
25/05/2010: Ireland 2-1 Paraguay, RDS
28/05/2010: Ireland 3-0 Algeria, RDS
11/08/2010: Ireland 0-1 Argentina, Aviva Stadium
03/09/2010: Armenia 0-1 Ireland, Yerevan
07/09/2010: Ireland 3-1 Andorra, Aviva Stadium
08/10/2010: Ireland 2-3 Russia, Aviva Stadium
12/10/2010: Slovakia 1-1 Ireland, Zilina
17/11/2010: Ireland 1-2 Norway, Aviva Stadium
08/02/2011: Ireland 3-0 Wales, Aviva Stadium
04/06/2011: FYR Macedonia 0-2 Ireland, Skopje
02/09/2011: Ireland 0-0 Slovakia, Aviva Stadium
07/10/2011: Andorra 0-2 Ireland, Andorra la Velle
11/10/2011: Ireland 2-1 Armenia, Aviva Stadium
15/11/2011: Ireland 1-1 Estonia, Aviva Stadium
29/02/2012: Ireland 1-1 Czech Republic, Aviva Stadium
04/06/2012: Hungary 0-0 Ireland, Budapest
10/06/2012: Croatia 3-1 Ireland, Poznan
14/06/2012: Spain 4-0 Ireland, Gdansk
18/06/2012: Italy 2-0 Ireland, Poznan
15/08/2012: Serbia 0-0 Ireland, Belgrade
07/09/2012: Kazakhstan 1-2 Ireland, Astana
12/10/2012: Ireland 1-6 Germany, Aviva Stadium
16/10/2012: Faroe Islands 1-4 Ireland, Torshavn
14/11/2012: Ireland 0-1 Greece, Aviva Stadium
06/02/2013: Ireland 2-0 Poland, Aviva Stadium
22/03/2013: Sweden 0-0 Ireland, Stockholm
26/03/2013: Ireland 2-2 Austria, Aviva Stadium
29/05/2013: England 1-1 Ireland, London
07/06/2013: Ireland 3-0 Faroe Islands, Aviva Stadium
14/08/2013: Wales 0-0 Ireland, Cardiff
06/09/2013: Ireland 1-2 Sweden, Aviva Stadium
10/09/2013: Austria 1-0 Ireland, Vienna
15/10/2013: Ireland 3-1 Kazakhstan, Aviva Stadium
15/11/2013: Ireland 3-0 Latvia, Aviva Stadium
19/11/2013: Poland 0-0 Ireland, Poznan
25/05/2014: Ireland 1-2 Turkey, Aviva Stadium
31/05/2014: Ireland 0-0 Italy, London
07/09/2014: Georgia 1-2 Ireland, Tbilisi
11/10/2014: Ireland 7-0 Gibraltar, Aviva Stadium
14/10/2014: Germany 1-1 Ireland, Gelsenkirchen
14/11/2014: Scotland 1-0 Ireland, Glasgow
29/03/2015: Ireland 1-1 Poland, Aviva Stadium
07/06/2015: Ireland 0-0 England, Aviva Stadium
13/06/2015: Ireland 1-1 Scotland, Aviva Stadium
04/09/2015: Gibraltar 0-4 Ireland, Faro
07/09/2015: Ireland 1-0 Georgia, Aviva Stadium
08/10/2015: Ireland 1-0 Germany, Aviva Stadium
11/10/2015: Poland 2-1 Ireland, Warsaw
16/11/2015: Ireland 2-0 Bosnia & Herzegovina, Aviva Stadium
29/03/2016: Ireland 2-2 Slovakia, Aviva Stadium
27/05/2016: Ireland 1-1 Netherlands, Aviva Stadium
13/06/2016: Ireland 1-1 Sweden, Paris
18/06/2016: Belgium 3-0 Ireland, Bordeaux
26/06/2016: France 2-1 Ireland, Lyon
05/09/2016: Serbia 2-2 Ireland, Belgrade
06/10/2016: Ireland 1-0 Georgia, Aviva Stadium
24/03/2017: Ireland 0-0 Wales, Aviva Stadium
List of Goals Scored
19/08/2003: Ireland 2-2 Australia, Lansdowne Road
15/10/2013: Ireland 3-1 Kazakhstan, Aviva Stadium
14/10/2014: Germany 1-1 Ireland, Gelsenkirchen