Osam's squad travel to Spain this week to play Germany in La Manga on January 12, before returning to Dublin to face Australia in the FAI National Training Centre on January 19.
14 players in Osam's squad are based in the SSE Airtricity League, and the Head Coach says the fact they are currently in pre-season means preparations for the upcoming matches are a challenge.
"We've been monitoring the players in recent weeks. Players going into international football need to be as close to their peak as possible. That won't be possible in the upcoming games," said Osam (pictured above).
"It's a challenge for the squad, but the international season goes on all year. We cannot turn down games, when opportunities like the upcoming fixtures arise."
Republic of Ireland Under-17 Head Coach Colin O'Brien will travel to La Manga to watch the team in action against Germany, and will also be in attendance the following week, when the team meet Australia.
Osam says the two games represent a chance for players to impress ahead of the UEFA Under-17 Championships later this year in Ireland.
"We don't have a massive pool of players at any age grade because of the size of the country. There is always potential for the Under-16s to push their way into the Under-17 squad.
"Colin [O'Brien] comes to a lot of our games. He wants to see if the players are good enough to play in the European Championships."
Republic of Ireland Squad
Goalkeepers: Arlo Doherty (Manchester City), Daniel Rose (Everton)
Defenders: Fionnan Coyle (Finn Harps), Anselmo Garcia MacNulty (Real Betis), Oisin Hand (Shamrock Rovers), Gavin O'Brien (Bohemians), Kevin Platon (Shamrock Rovers), Adam Wells (Shamrock Rovers)
Midfielders: Colin Conroy (Bohemians), Oran Crowe (Cork City), Jamie Doyle (St. Patrick's Athletic), Kyle Martin-Conway (St. Patrick's Athletic), Ben McCormack (St. Patrick's Athletic), Andrew Moran (Bray Wanderers)
Forwards: Sinclair Armstrong (Shamrock Rovers), Dylan Gavin (Athlone Town), Calum Kavanagh (Middlesbrough), Billy Vance (Bray Wanderers)
Fixtures:
12/1: Republic of Ireland v Germany, La Manga Club, Spain, KO: 16:00 (15:00 Irish Time)
19/1: Republic of Ireland v Australia, FAI National Training Centre, KO: 13:00