The U-21s are set to travel to Yerevan, Armenia for their qualifier on Thursday, November 14, with kick-off at 12pm (4pm local time), before returning to Ireland to face Sweden on Tuesday, November 19, with kick-off at 8pm.
Captain Jayson Molumby and defender Lee O'Connor are both suspended for the Armenia qualifier but will link up with the squad ahead of the Sweden match.
Aston Villa's Jack Clarke receives his first U-21 call-up as well as Hearts striker Aidan Keena and full-back Thomas O'Connor, who is currently on loan at Gillingham from Southampton.
Stephen Kenny's squad has also been boosted by the return of Trevor Clarke, who has returned to full fitness, and receives his first call-up since the victory over Luxembourg in March.
Ireland will be without Jonathan Afolabi, Darragh Leahy and Luca Connell who are out injured, and Troy Parrott, who has been called into the senior squad.
Gavin Bazunu will link up with the Republic of Ireland U-19 squad ahead of their UEFA qualifying round matches this month.
Tickets for the Sweden qualifier are currently on sale for €5 adults and FREE for U-16s, FAI Season Ticket Holders and Shamrock Rovers Season Ticket Holders. Get your tickets from fai.ie/tickets now.
Republic of Ireland U-21 Squad
Goalkeepers: Caoimhin Kelleher (Liverpool), Conor Kearns (UCD AFC).
Defenders: Thomas O'Connor (Gillingham, on loan from Southampton), Danny McNamara (Newport County, on loan from Millwall), Dara O'Shea (West Bromwich Albion), Conor Masterson (QPR), Liam Scales (UCD AFC), Nathan Collins (Stoke City), Trevor Clarke (Rotherham).
Midfielders: Jason Knight (Derby County), Conor Coventry (West Ham United), Jack Taylor (Barnet), Jack Clarke (Aston Villa), Connor Ronan (DAC Dunajská Streda, on loan from Wolverhampton Wanderers), Dan Mandroiu (Bohemians).
Wingers: Zack Elbouzedi (Waterford), Gavin Kilkenny (AFC Bournemouth), Neil Farrugia (Shamrock Rovers), Danny Grant (Bohemians).
Forwards: Adam Idah (Norwich City), Aidan Keena (Hearts), Michael Obafemi (Southampton).