It is the first time the team will play in 2018, as they return to action after two international friendlies at home to Poland last November.
Speaking after his squad announcement, Donohue revealed he has been keeping an eye on players since the Poland games.
"We've had some assessments and watched plenty of players. We have made seven changes from the last squad, giving plenty of players in form the chance to impress."
The quality of players in the SSE Airtricity League Under-15 National League has also helped Donohue pick players for the Cyprus games he admitted.
"All of the home-based players are playing in the Under-15 National League. The gap is closer now to international football, because they are playing at an elite level."
The first match between the two sides takes place on Tuesday, March 6 in Longford's City Calling Stadium. Kick-off is at 19:00.
Republic of Ireland Under-15 squad
Goalkeepers: Daniel Rose (Everton), Patrick McGarvey (Finn Harps)
Defenders: Anselmo Garcia McNulty (Real Betis), Conrad Egan Riley (Manchester City), Gavin O'Brien (Bohemian FC), Len O'Sullivan (Bohemian FC), Ronan Kilkenny (Bohemian FC)
Midfielders: Ben McCormack (St. Patrick's Athletic), Bosun Lawal (Bohemian FC), Colin Conroy (Bohemian FC), Evan Caffrey (Shamrock Rovers), Kailin Barlow (Sligo Rovers), Kyle Conway (St. Patrick's Athletic), Oran Crowe (Cork City), Sami Clarke (Shamrock Rovers), Val Adedokun (Dundalk)
Forwards: Calum Kavanagh (Middlesbrough), Louie Barry (West Bromwich Albion)
Fixtures
Tuesday, March 6
Republic of Ireland v Cyprus, City Calling Stadium, KO 19:00
Thursday, March 8
Republic of Ireland v Cyprus, City Calling Stadium, KO 13:00